Stephan Baldus, M.D.
Volker Rudolph, M.D.
Anna Klinke, Ph.D.
Heart Center, Department of Cardiology
University Hospital Cologne
Stephan Baldus, Cologne, Germany
Michael Davies, Copenhagen, Denmark
Jason Eiserich, Sacramento, United States
Tony Kettle, Christchurch, New Zealand
Anna Klinke, Cologne, Germany
Lukas Kubala, Brno, Czech Republic
William Nauseef, Iowa, United States
Christian Obinger, Vienna, Austria
Stephan Rosenkranz, Cologne, Germany
Volker Rudolph, Cologne, Germany
Invitation to Participate
We are currently organising the 9th International Human Peroxidase Meeting, scheduled to be held in September 2015 in Cologne. The International Human Peroxidase Meetings represents the foremost meeting series focussed on all research (from basic science to clinical studies) into the mammalian heme peroxidases, with particular interest in their role in human health and disease. We are expecting to welcome many of the world’s leading experts on various aspects of human peroxidase enzymes and anticipate that ca. 80 – 100 delegates will come to Germany for this meeting. We would like to invite you to participate in the 2015 meeting.
History of the Human Peroxidase Meetings
The first official meeting of this series comprised of a one day symposium entitled “Recent Developments in MPO deficiency” which was held in 1996 in Luxembourg. The delegates present at this first meeting decided that a regular meeting encompassing a much wider view of peroxidase research should be held. Consequently, in 1998 the second meeting of the series, entitled “The Peroxidase Multigene Family of Enzymes: Biochemical and Clinical Applications”, was held at Lake Chiemsee in Germany. Since this meeting, experts from around the globe have been meeting every 2 – 3 years to present their research on the human peroxidase enzymes all over the world (Vienna, Kyoto, Akaroa, Chapel Hill and Brussels). Recent meetings have focussed on advances in the understanding of the structure, function and pathophysiology of these enzymes.
What are the mammalian heme peroxidase enzymes?
The mammalian heme peroxidase enzymes (including myeloperoxidase, eosinophil peroxidase, lactoperoxidase, thyroid peroxidase, vascular peroxidase and cyclooxygenases) have all gained attention over the past two decades as their contribution to both human health and the development of human pathologies has become increasingly recognised. Many of these enzymes are secreted by activated white cells and play key roles in innate host defense, via the production of potent oxidants with bactericidal and bacteriostatic properties. However, these same enzymes, as well as their associated oxidants, have also been implicated in the progression of numerous inflammatory diseases, including cardiovascular diseases (e.g. atherosclerosis), lung pathologies (e.g. asthma, cystic fibrosis), neurodegenerative disorders, kidney disease, inflammatory cancers, rheumatoid arthritis, to name but a few.
This realisation has led to increased knowledge of many aspects of the human peroxidase enzymes, including, (i) the basic chemistry and biochemistry of these enzymes and their oxidants, (ii) the development of specific biomarkers and bioassays allowing detection of these enzymes and peroxidase-mediated damage at most, if not all, sites of inflammation, (iii) the polymorphisms that mediate the levels of these enzymes in vivo.
Scope of the Meeting
There is still much to be learnt about the peroxidases, and we anticipate that many new and exciting advances will be presented at the meeting, such as continuing studies on the diagnostic and prognostic use of these enzymes in various diseases, their role in innate host defense, the development of peroxidase inhibitors as therapeutic agents, the development of functional imaging modalities based on peroxidase activity as well as further insight into the basic biochemistry of these complex enzymes. These meetings are always attended by many of the world leaders in clinical and basic research related to mammalian heme peroxidases, and much of the work presented at these meetings is published in extremely high quality scientific journals.